A funeral mass was held July 6 at St. Peter the Apostle Church, River Edge, for Michael N. Losito, better known as “Mike Marine”, 93, a resident of Secaucus. He passed away July 3 at Villa Marie Claire in Saddle River. Born and raised on Adams Street in Hoboken, he served in the Civilian Conservation Corps (CCC) and defended this country in the United States Marine Corps (USMC) in the Japanese theater of World War II, fighting in the battles of Saipan, Tinian, and Okinawa. After the war, he began his career on the NY/NJ waterfront as a longshoreman, checker, hiring agent, and stevedore superintendent throughout his 50 plus years. In 1951, he married his wife Marie Ceglie at St. Francis Church in Hoboken. Michael is survived by his wife Marie, his son John, and his son Carl and his wife Bernadette. He is also the grandfather of Michael and his wife Julia, John, Carl, Jr., and Maria, as well as the great-grandfather of Daniel and Grace.Services arranged by the Beaugard-McKnight Funeral Home, River Edge.
For years, doctors treating HIV have recognized a relationship between how faithfully patients take prescribed drugs and how likely the virus is to develop drug resistance. More recently, research has shown that the relationship between adherence to a drug regimen and resistance is different for each of the drugs that make up the “cocktail” used to control the disease.New research by Harvard scientists could help explain why those differences exist, and may help doctors quickly and cheaply design drug combinations less likely to result in resistance.A team led by Martin Nowak, professor of mathematics and of biology and director of the Program for Evolutionary Dynamics, has developed a technique for modeling the effects of various treatments and for predicting whether the treatments will cause the virus to develop resistance. The work is described in a paper in Nature Medicine.“What we demonstrate in this paper is a prototype for predicting, through modeling, whether a patient at a given adherence level is likely to develop resistance to treatment,” said Alison Hill, a Ph.D. student in biophysics in the Graduate School of Arts and Sciences (GSAS) and co-first author of the paper. “Compared to the time and expense of a clinical trial, this method offers a relatively easy way to make these predictions. And, as we show in the paper, our results match with what doctors are seeing in clinical settings.”The hope, said Nowak, is that the new technique will take some of the guesswork out of what is now largely a trial-and-error process.“This is a mathematical tool that will help design clinical trials,” he said. “Right now, researchers are using trial and error to develop these combination therapies. Our approach uses the mathematical understanding of evolution to make the process more akin to engineering.”Developing a model that can make such predictions required huge amounts of data.Hill and Daniel Scholes Rosenbloom, a GSAS Ph.D. student in organismic and evolutionary biology and another co-first author, turned to the Johns Hopkins University School of Medicine, where Professor Robert F. Siliciano was working with Ph.D. student Alireza Rabi (also a co-first author) to study how the HIV virus reacted to varying drug dosages.Their research proved critical to the model that Hill, Rabi, and Rosenbloom eventually designed, because the level of the drug in patients — even those who adhere to their treatment perfectly — varies. When drug levels are low — as they are between doses, or if a dose is missed — the virus is better able to replicate and grow. Higher drug levels, by contrast, may keep the virus in check, but they also increase the risk of mutant strains of the virus, leading to drug resistance.Armed with the data from Johns Hopkins, Hill, Rabi, and Rosenbloom created a computer model that could predict whether and how much the virus, or a drug-resistant strain, was growing based on how strictly patients stuck to their drug regimen.“Our model is essentially a simulation of what goes on during treatment,” Rosenbloom said. “We created a number of simulated patients, each of whom had different characteristics, and then we said, ‘Let’s imagine these patients have 60 percent adherence to their treatment — they take 60 percent of the pills they’re supposed to.’ Our model can tell us what their drug concentration is over time, and based on that, we can say whether the virus is growing or shrinking, and whether they’re likely to develop resistance.”The predictions, Rosenbloom explained, can then serve as a guide to researchers as they work to design drug cocktails to combat HIV.Hill and Rosenbloom said they plan to continue to refine the model.“The prototype we have so far looks at concentrations of drugs in blood plasma,” Rosenbloom said. “But a number of drugs don’t penetrate other parts of the body, like the brains or the gut, with the same efficiency, so it’s important to model these other areas where the concentrations of drugs might not be as high.”Ultimately, though, the model provides new hope to patients by helping doctors design better, cheaper, and more-efficient treatments, the researchers said.“Over the past 10 years, the number of HIV-infected people receiving drug treatment has increased immensely,” Hill said. “Figuring out what the best ways are to treat people in terms of cost-effectiveness, adherence, and the chance of developing resistance is going to become even more important.”
Chris O’Dowd Show Closed This production ended its run on July 27, 2014 View Comments Related Shows Star Files Of Mice and Men Better hope your Airbnb hosts don’t watch Late Night or read Broadway.com, Chris O’Dowd. The Of Mice and Men Tony nominee revealed to Seth Meyers that he and his wife basically ignore the “no pets” rule and smuggle their dog and cat into their rented New York apartments. The actor also shared that he was “mid-spoon” when he heard the news about his Tony nod (we also hear that he was naked and eating waffles). In addition to a Tony nomination, O’Dowd’s Broadway debut has also caused the actor to look like he’s “eaten Russell Crowe,” bond with fellow Broadway Lennie James Earl Jones and photobomb a certain EGOT-er. Take a look at the hilarious and revealing interview below!
By Dialogo April 09, 2013 At a symposium about Latin America held in Miami, Colombian Minister of Defense Juan Carlos Pinzón said that most Colombians are no longer frightened by terrorism and organized crime. “Today, for the average Colombian citizen, terrorism is something that is seen on television but that no longer affects them directly,” Pinzón said to an audience of academics, diplomats, businessmen, university students, journalists, and military personnel that attended the event organized by the Center for Hemispheric Policy at the University of Miami. Pinzón attributed this change to the efforts made for over a decade, among which he recognized the progress made by the governments of Andrés Pastrana, Álvaro Uribe, and current President Juan Manuel Santos, as well as the boost given by Plan Colombia –which the United States carried out, calling it “a relatively small investment with a huge impact.” “Since Plan Colombia started, we increased training in special operations, technologies used for intelligence-gathering, counter drug efforts, as well as cooperation. As a result, we have seen a change in the threat we are confronting,” the minister said. According to Pinzón, who has been Minister of Defense for 19 months, the Revolutionary Armed Forces of Colombia (FARC) had 21,000 combatants, as well as 20,000 militias in 2000. Between 2010 and 2011, that figure was reduced to 9,000 armed guerrillas and 10,000 militias, and by “late 2012, there were less than 8,000 armed terrorists, and 9,000 militias,” he stated. As for the future of peace talks with the FARC, the minister said, “personally, I think the battle against terrorist organizations will continue for several months, but no longer than five years, because if these individuals do not understand that this is their last chance, they will continue to weaken in their position to the extent that they will become no more than an ordinary criminal gang,” he concluded. The VIII Latin America Symposium, created by the Center for Hemispheric Policy at the University of Miami, also featured the participation of regional experts, who discussed topics such as the changing Latin American political environment, commercial relations between the United States and Latin America, the future of Venezuela, and the role of regional economies, namely those of Mexico, Brazil, Argentina and Chile, on the region as a whole. The topic of Venezuela, which captured the attention of participants and panelists, was addressed by Professor Javier Corrales from the Political Science School at Amherst College, in Massachusetts. According to the scholar, the leftist movement that was led by late President Hugo Chávez reached its peak, and is now in decline. Other participants, such as Brian Latell, a fellow researcher from the Institute for Cuban & Cuban-American Studies at the University of Miami, even said that if Nicolás Maduro was elected, he will face too many difficulties to keep ‘Chavism’ alive. Among the speakers was Brazilian Ambassador to the U.S. Mauro Vieira, who said that since 2000, the combination of an accelerated economic development, a low unemployment rate, and a controlled inflation in Brazil has favored the increase of national and foreign investment in the country. For example, the diplomat said that during 2012, a considerable increase in U.S. investments was observed in his country at the same time as Brazilian companies were seen investing in U.S. capital. “We are united by bonds that can be traced back to 1822, when the U.S. was the first country to recognize Brazil as a democratic state,” he said. The Brazilian Ambassador in Washington also stressed that the social policies applied by the governments of Luiz Inácio Lula da Silva and Dilma Rousseff allowed 24 million people to step out of poverty, and 31 million others to become part of the middle class.
By Roberto Caiafa/Diálogo May 11, 2017 The KC-390, the result of an order placed by the Brazilian Air Force with demanding requirements, is an aircraft with a robust airframe, equipped with high wings fixed with engines positioned to avoid debris intake, a T-shaped tail with an automated loading ramp, main landing gear stowed within large aerodynamic structures with tailor-made doors, lateral doors for parachute launching equipped with special aerodynamic deflectors, a wide nose (housing a modern radar), and dual wheel landing gear. Designed to transport up to 26 tons, the KC-390 achieves that performance thanks to a pair of V-2500 engines – the same type used in various commercial jets. An added bonus to this popular propulsion model engine is its wide offering of parts and services, in addition to the ease of maintenance. “The modern and spacious cockpit has large windows that afford the crew great situational awareness,” stated Valtécio Alencar, Communications executive at Embraer Defense & Security (EDS, as per its Portuguese acronym). Alencar was in charge of presenting the aircraft at LAAD Defence and Security 2017. “The instrumentation panel, which is dominated by large colored screens, uses Pro Line Fusion digital avionics technology. The fly-by-wire flight controls are sidestick, with advanced ergonomics and a lot of comfort for the crew who have air conditioning and electronically controlled seats,” he explained. The cargo compartment, which is the plane’s reason for being, is very well equipped. Its multipurpose deck uses the concepts of turning, opening, clicking, locking, closing, attaching, and anchoring, all taken to their maximum potential. To change from a flat cargo floor to roller configuration, all that is needed is to turn the guides and the conversion is done. The same thing is done to air drop cargo on pallets: open, lock, and leave the guides in position, and the pallets slide out of the plane. To anchor loads and keep them stable, there are various kinds of anchorage points and straps for vehicles, pallets, or bundles. To drop paratroopers from the plane, there are anchoring cables with parachute hooks, signal lights, and other equipment. The lateral doors allow for safe jumping, free from buffeting winds. The effect is achieved through the use of aerodynamic deflectors that are attached to the fuselage when they are not in use. The Cargo Handling System is used to maintain, monitor, and execute precision air drops of cargo, vehicles, and troops through a variety of tactical methods. This includes a station for the loadmaster, a network of lock control units and control panels for detecting, measuring force, activating, and releasing locks. Thus, service members have at their disposal a set of modern engineering tools and the fuselage measurements (length x width x height) to facilitate the shipment of any number of cargo configurations, pallets, containers, vehicles, specialized vehicles, armored vehicles, engineering equipment, and much more. Additionally, and to expand its operational reach, the KC-390 has a probe for in-flight refueling. That way, it can take on fuel from another aircraft with the same capabilities, vastly extending its autonomy and operational radius. New KC-390 tests Soon, the KC-390 must undergo tests transporting Guarani VBTP-MR 6×6 armored vehicles. This is a longstanding requirement put in place by the Paratrooper Infantry Brigade and by the Rapid Response Forces, both professional troops in the Brazilian Army. Armored vehicles in their standard configuration, as well as versions equipped with REMAX, REMAN, and UT-30BR weapons turrets will be used in the testing. The armored version with the TORC30 turret (30 mm cannon) must undergo the same tests as soon as it is integrated with the Guarani armored vehicle and is available. These tests aim to remove any doubts about the plane’s capacity to provide the Paratrooper Infantry Brigade with the immediate transport of combat-ready armored vehicles without the need for any kind of procedure to mount or dismount turrets or weapons stations. In practice, these tests will prove that there are proper communication and information sharing among the managers of the strategic projects vital to the two Brazilian Armed Forces. According to Major General Edson Henrique Ramires, the project manager for the VBTP-MR 6×6, “the Guarani is key to ensuring the mobility and shock power of the Brazilian Expeditionary Forces, and the KC-390 is the ‘silver bullet’ in this strategy, as it delivers armored vehicles, supplies, munitions, troops, and other equipment to the field directly on unfinished runways in just a few hours.” To survive on the front lines in this dangerous environment, the aircraft is equipped with an advanced defensive suite consisting of warning sensors for missile approach, pyrotechnic launchers, and a directional infrared countermeasure system capable of interfering with the guidance head on heat-seeking missiles. This model also employs enhanced vision sensors in bad weather, where the image is projected on large screens installed at eye level in the cockpit. The functionality to land in poor visibility allows the KC-390 to operate safely in adverse weather conditions. A colored camera installed in the cockpit will record the scene of the pilot superimposed over the data generated by the sensor system, in order to analyze the missions. “The KC-390 plane was created to furnish mobility and robustness to the Brazilian Armed Forces, containing the highest level of technology added to the product. This project was guided by high operational flexibility, and by the ease of maintenance throughout the useful life cycle of this model, even in terms of the cost per flight hour. Progress in these tests and the next stages of development will serve to cap off the expectations that have been placed on this product,” said Paulo Gastão, the KC-390 project manager for EDS.
by: Chloe Della CostaMost employees know it’s usually a good idea to take advantage of benefits such as retirement savings, medical insurance, and paid vacation days. What they may be forgetting, however, is that many companies offer more perks, many of which provide the opportunity to save both time and money. We’re not just referring to the over-the-top game rooms and gourmet meals that employers like Google use to attract talent and media attention. There are a lot of very practical benefits employers provide that seem to fly under the radar.Then there are the benefits like paternity leave and transgender health coverage that ought to be universal, but somehow still aren’t. More employers are catching on to benefits like these, and whether they are instituted for the good of the employees, for increased productivity and loyalty, or for the employer’s reputation alone, workers would be unwise to miss out on any perk that comes with the job.That’s not to say everything an employer offers will be the right fit for every employee, but it’s a good idea to at least do a thorough check on what’s offered. Sometimes not all benefits are widely talked about by human resources managers, and it can be easy to miss the occasional email touting a special employee discount or perk. If you are taking advantage of your 401k company match and a worthwhile health plan, that’s a great place to start. But you could be missing out on savings elsewhere. If you’re lucky enough to work at a company that offers additional employee benefits, here are some of the perks worth considering. continue reading » 5SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
U.S. Consumers and the Branch. There is no denying that the number of branches in operation today is less than before the great recession. However, simply pointing out there are fewer branches is only part of the story. For example, when you consider a recent a IMF study, the number of branches is rising.Per their research, the peak of branches per capita was 35 branches in 2009. The low point was 33 in 2014 – the same level as 10 years earlier. But in 2015, the number of branches per 100,000 started rising again.Let’s Talk about the S-Word. So instead of another article focusing on if the branch is important, let’s talk about one of the key steps in making sure when you do branch – you get what you want. Let’s talk about Site Selection.Good to Great: Site SelectionFirst Things First. The first step in site selection is not the real estate procurement, but establishing the business case. Site selection is the marriage of market analysis and real estate procurement. continue reading » 7SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
Tioga State Banks: Upper Front Street, Vestal, Endwell, Spencer, and Owego locationsEndwell Family Physicians. JOHNSON CITY (WBNG) — WBNG is hosting a Backpack Giveaway now through Sept. 11. One place you can drop off a backpack Hatala Orthodontics at 165 Riverside Dr. in Johnson City. The other locations you can drop off a backpack are: You can also ship the backpacks directly to Hatala Orthodontics.
This property at 390-402 Benhiam St, Calamvale, has sold for $7m. Picture: realestate.com.auA CHINESE buyer has paid $7 million in cash for a huge property with two titles in the outer Brisbane suburb of Calamvale — but he has no plans to develop it.The large six-bedroom, brick home on a huge 20,400 sqm site at 390-402 Benhiam Street attracted more than 100 people to its first open home, but there was one offer the owners couldn’t refuse.A Chinese buyer has paid $7m cash for this property at 390-402 Benhiam St, Calamvale. Picture: realestate.com.auRay White Sunnybank Hills principal Eric Li, who negotiated the sale, said the buyer offered $7 million in cash unconditional with a two week settlement on the spot.Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 1:15Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -1:15 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD540p540p360p360p270p270pAutoA, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenThe magic of compound interest01:15“He just wanted to buy straight away,” Mr Li said.“He could see the competition and didn’t want to miss out.”GET THE LATEST REAL ESTATE NEWS DIRECT TO YOUR INBOX HEREMr Li said the buyer had been looking for a big block of land in the area and was very keen to buy.More from newsMould, age, not enough to stop 17 bidders fighting for this home3 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor3 hours agoThe property at 390-402 Benhiam St, Calamvale, has two titles. Picture: realestate.com.auPerhaps surprisingly, he plans to move straight in with no intentions of developing the property.Mr Li said it was another example of the appetite from Chinese buyers for property in the Sunnybank area.What is Hamptons style?Golf course home breaks recordBrisbane property on the riseThe house itself is about 25 years old and has five bathrooms and a 10 car garage.It’s close to public transport, local shops and Sunnybank.The property had been marketed as having “huge future development potential”.Calamvale is 17km from the CBD and has a median house price of $650,000.
The strike by academic staff at UK universities over changes to the Universities Superannuation Scheme (USS) is clearly damaging for students and it is a sad state of affairs that other means of discussion were not able to resolve the issues.USS is the UK’s largest pension scheme and the issues it faces are reflective of the issues faced by any still open defined benefit pension schemes. In the case of the USS, there is another factor to bear in mind, which is that universities are public entities and indeed, staff at newer universities are on a different scheme.One of the key issues in the debate is how much risk the fund should take and indeed, how that risk should be measured. Liabilities are priced off the back of Gilt yields that are themselves artificially depressed through quantitative easing, while the risk management approach of liability-driven investment (LDI) forces the purchase of Gilts irrespective of price.Assuming such low yields will persist forever and that pension funds need to be able to fund liabilities on that basis is the reason why defined benefit transfers have become so attractive for some individuals. Some schemes have been offering transferees multiples in the region of 40 times projected annual pension income. For those willing to take capital risk – which clearly may not suit everyone – the income yield on a diversified portfolio including equities would easily beat yields of 2% available on 30-year Gilts. But what may be suitable for some individuals seems impossible for a fund, even though the fund has a much longer time horizon. But should open defined benefit pension schemes be so concerned about mark-to-market capital fluctuations if there is no intention to close the scheme down?Some would argue that LDI-driven fixation on purchasing sovereign debt irrespective of the price is a form of financial repression. The driving forces have been a mixture of accounting changes, regulatory issues and the underlying movement towards treating LDI as a purely risk management problem. These have set in stone the present values of pension liabilities based on government bond yields that we know will change each year.The net result is that matching pension liabilities is seen as a risk management issue rather than an investment issue, so pricing of debt has become irrelevant. Pension funds are therefore unable to invest in long-term risky assets, whether in the UK or overseas, despite having long-term liabilities.But the ultimate risk taker in a country is the state itself. There is a case to be made for setting up a UK sovereign wealth fund financed by issuing Gilts sold to UK pension funds. This would, in effect, be acting as an intermediary guaranteeing pension funds the ability to meet their liabilities whilst generating much higher cashflows from elsewhere.The House of Commons debated the idea in December 2016. One of the briefing papers for the debate was an article I wrote in 2012 for IPE. In the article, I had suggested that given an aging population, the UK should set up a sovereign wealth fund to add to tier one pension provisions. As MPs pointed out in the debate, there is an issue of inter-generational justice when it comes to allocating resources within a country. An increasing aging population cannot expect to solely rely on the Ponzi-type economics of taxing a declining younger population for future pensions.Investing a sovereign wealth fund in emerging market equities, for example, with many funds currently offering yields well in excess of 4% and even 5% in some cases, would easily cover the cost of the Gilt coupons while receiving dividends produced by younger populations outside the UK.A sovereign wealth fund may have some benefits for the USS. More issuance of Gilts will push yields up a bit, thereby reducing liabilities and the deficit. But perhaps the real issue is a political decision on whether LDI valuations are appropriate for a public sector entity.